Enhancement of Dissolution Properties of Amlodipine Besylate Using Liquisolid Technique

The most promising method for enhancing solubility, therefore promoting the rate of dissolution is the formation of liquisolid compacts.[2]With Liquisolid technique as described by Spireas liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders, by simple physical blending with selected excipients named the carrier and the coating material. The liquid portion can be a liquid drug, a drug suspension or a drug solution in suitable non-volatile liquid vehicles. Once the carrier is saturated with liquid vehicle, a liquid layer is formed on the particle surface which is instantly adsorbed by the fine coating particles. Hence, an apparently dry, free flowing, and compressible powder is obtained. Generally, various grades of microcrystalline cellulose (MCC) are used as carrier material and various grades of amorphous silicon dioxide (colloidal silica) as coating material.[3-6]